nm23-H1 protein immunoreactivity in laryngeal carcinoma
نویسندگان
چکیده
منابع مشابه
NM23-H1 and NM23-H2 messenger RNA abundance in human hepatocellular carcinoma.
nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems. Subsequently, two related human nm23 genes, nm23-H1 and nm23-H2, were identified. The relationship between expression of nm23-H1 and nm23-H2 in hepatocellular carcinoma specimens from 30 patients and metastatic potential was investig...
متن کاملExpression and significance of heparanase and nm23-H1 in hepatocellular carcinoma.
AIM To explore the relation between heparanase (HPA) and nm23-H1 in hepatocellular carcinoma (HCC), and whether they could be used as valuable markers in predicting post-operative metastasis and recurrence of HCC. METHODS Reverse transcription-polymerase chain reaction and immunohistochemistry (S-P method) were used to measure the expressions of HPA mRNA and nm23-H1 protein in primary tumor t...
متن کاملExpression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma
The expression of non-metastatic expressed/non-metastatic 23 nucleoside diphosphate kinase 1 (nm23-H1) and cyclooxygenase 2 (COX-2) proteins in thyroid carcinoma have been analysed in a number of previous studies, but this requires further study. The current study focused on the expression levels of nm23-H1 and COX-2 in 130 human thyroid papillary carcinoma (PTC) tissues. Of the 130 PTC tissues...
متن کاملPrognostic significance of nm23-H1 expression in esophageal squamous cell carcinoma.
OBJECTIVES Tumor recurrence and metastasis are major causes of treatment failure in esophageal squamous cell carcinoma (ESCC). Recently, nm23, originally considered to be an anti-metastatic gene, has been reported to associate with various roles in different human cancers. We therefore investigated the clinical significance of nm23-H1 expression in ESCC. METHODS Pathological sections were imm...
متن کاملRoles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal squamous cell carcinoma
BACKGROUND Lymphatic metastasis contributes to the poor prognosis of laryngeal squamous cell carcinoma (LSCC). This study aimed to investigate the roles of two metastasis suppressor genes, KAI1 and nm23, in lymphangiogenesis and lymph metastasis of LSCC. METHODS A total of 45 LSCC patients were enrolled in this study. The positive expression rates of KAI1 and nm23 protein were detected via im...
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ژورنال
عنوان ژورنال: Cancer
سال: 1996
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19960601)77:11<2246::aid-cncr10>3.0.co;2-x